Telluride Science is a nonprofit organization that focuses on small, interdisciplinary, think-tank-style meetings to promote advancements in science and technology. Established in 1984 and headquartered at the National Historic Telluride Depot, the organization serves over 1,400 scientists and engineers annually from approximately 500 international and domestic institutions. Telluride Science enhances research productivity across various fields including biomedical science, energy, material science, water, climate, quantum computing, and fundamental sciences.

In addition to fostering scientific collaboration, Telluride Science's facility, the Telluride Innovation Center, serves as a premier event venue in Telluride. Nestled along the San Miguel River, the Telluride Innovation Center offers an elegant and versatile venue for weddings, rehearsal dinners, special celebrations and corporate retreats.